DENVER - The Bills held Peyton Manning to 173 yards passing, forced him into two interceptions, even put a halt to his 51-game streak with a touchdown throw. Heck, Kyle Orton, the former Broncos quarterback who lost his job to Tim Tebow, more than doubled Manning in yards.If only Buffalo had kept those other numbers down — penalties, its own turnovers and missed opportunities — this wouldve been a day to remember. Instead, Orton and the Bills managed a field goal and a couple desperation touchdowns and fell 24-17 to the Broncos on Sunday.The defeat hurt them in the wild-card chase and hurt doubly because they slowed down Manning but squandered the opportunity.There were no surprises, Bills running back Fred Jackson said. We watched them on film all week. We knew what they were capable of doing. When you want to beat a good team, you cant have those penalties, those turnovers. Thats something were well aware of.The Bills (7-6), now in a five-way tie, one game behind the last wild-card teams, had three turnovers.But it was the penalties that hurt the most. They committed 11 for 98 yards. Two of them nullified interception returns of 60 and 48 yards that wouldve set them up nicely in Denver territory. The second, a 15-yarder on Corey Graham, wiped out most of Stephon Gilmores return, which would have given the Bills the ball on Denvers 35 midway through the third quarter with Buffalo trailing 21-3.Broncos centre Will Montgomery dived at Grahams knees while Graham was blocking during the return.Oh, it was a killer, Graham said. For me, it was a killer, too. The guy cut me when Im trying to block him. They dont call that, though. But they call me for retaliating.This marked the first time Manning has been held without a touchdown pass since Nov. 14, 2010, meaning Drew Brees will hang onto the record for at least a couple more years.It also marked the first time since last November in New England that Manning has been held under 200 yards passing. He finished 14 for 20 with a pedestrian passer rating of 56.9. And even though the Bills went without a sack for the first time this season, they kept the Broncos from making backbreaking plays. Mannings biggest completion was a 38-yarder to Wes Welker.All of which should have lessened the pressure on Orton, the journeyman who beat the Broncos 7-3 when he returned with Kansas City to close the 2011 season, only months after he was benched for Tebow, then traded away.Orton had 355 yards, most of them after the Bills had fallen behind by three touchdowns in the third quarter. Like Manning, he threw two interceptions. The first came after hed moved the Bills inside the Denver 20 midway through the third quarter, down by 18, when there was still enough time to mount a legitimate comeback.Not good enough to beat a good football team, Orton said when asked how he felt he played.From a pure yardage standpoint, the Bills defence got more than a passing grade, holding Denvers newest threat on offence, C.J. Anderson, to 58 yards on 21 carries and holding the entire Broncos offence to 306 yards, its lowest output of the season.Still, Anderson scored all three of Denvers touchdowns. And Buffalo couldnt stop his backup; Juwan Thompson carried it four times for 63 yards, including a 47-yard gain that set up Denvers third touchdown.Those things hurt. The penalties hurt worse.Jerry Hughes, a key to Buffalos recent success on defence, got hit with an unsportsmanlike-conduct penalty in the second quarter and spent virtually the rest of the game on the sideline.Coach Doug Marrone, who blamed himself for setting a bad example with a couple emotional outbursts on the sideline, said Hughes initially was pulled to calm him down, but said he wasnt aware the fifth-year lineman had barely played after that.Asked about the penalty, Hughes said he didnt remember what happened. But he took responsibility for a play that defined the day for Buffalo.It was self-inflicted, he said. We have to play better, plain and simple.Notes: Buffalos only injury was to S DaNorris Searcy (hamstring). ... Jackson caught 10 passes for 37 yards and ran for 35. ... The Bills still need one more win for their first eight-win season since 2004. Next up: The Packers at home.___AP NFL website: www.pro32.ap.org and www.twitter.com/AP_NFLBlank Jersey . 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The kids had it under control. Allen Craig and Matt Adams each had two RBIs and the St. Louis Cardinals got effective work from rookie pitchers subbing for their ace in a 6-2 victory over the New York Mets on Monday night. Nick Greenwood won his major league debut, with his fiancee, mother, agent and a close friend watching. "You couldnt ask for a better outing," Greenwood said. "Its awesome. Words cant describe." Carlos Martinez allowed an unearned run in four innings in his second career start and Greenwood (1-0) allowed a run and two hits in 3 1-3 innings for St. Louis, which has won seven of eight. "I dont know that you could ask any more," manager Mike Matheny said. "Today could have been a really tough day on our bullpen." Wainwright is skipping a turn to allow for tendinitis in the back of his elbow to subside. He is expected to return Saturday against the Phillies. Matt Holliday had two hits, including a single for his 1,000th career RBI in a four-run fifth that put the Cardinals up 6-1. He tipped his helmet to the crowd, and then scored standing up on Craigs double. "Hes pretty stoic most of the time," Matheny said. "But I mentioned something to him and he had a big smile." Mets manager Terry Collins batted the pitcher eighth for the first time in franchise history but the novel lineup with rookie Jacob deGrom in the eighth slot ahead of Eric Young Jr. mustered just five hits. New York has lost 10 of 13, scoring two or fewer runs six times. "We scored a run, it was fine, it worked out all right," Collins said. But he wouldnt say whether hed try the ploy again Tuesday, saying "I have no idea." Adams homered in his first three games coming off the 15-day disabled list from a strained left calf. One of his RBIs on Monday came on his third triple, tied for the team lead, and he stung the ball all four at-bats. "He runs well, he runs deceptively well," Matheny said. "Id much rather watch him trot." DeGrom (0-4) gave up six runs and 12 hits in 4 1--3 innings in his seventh career start, all three numbers statistical low points.dddddddddddd. "I just look at how many balls were really hit hard," he said. "Three or four were hit hard, the rest just kind of found holes and went through." The 25-year-old deGrom has allowed 13 runs and 26 hits in 15 innings over his last three starts. He handled the bat fine, with a sacrifice in the third and a broken-bat liner to second with the base loaded in the fourth after Ruben Tejada was intentionally walked. Young, activated from the 15-day disabled list before the game, had an infield hit to help manufacture a run in the third. But Martinez struck him out to end the fourth. "I havent seen one of those sliders like that in a couple weeks," Young said. "Its just a timing thing. But he made his pitch when he needed to and you tip your cap." The 22-year-old Martinez is one of the Cardinals top rotation prospects with a fastball that registered triple digits in the first inning. Hes been a setup man most of the year with a previous long outing of 2 2-3 innings and needed just 14 pitches to retire the Mets in order the first two innings. The Cardinals selected the 26-year-old Greenwoods contract from Triple-A Memphis on Sunday to provide support behind Martinez. Greenwood grew up a Yankees fan and walked the first batter he faced, former Yankee Curtis Granderson. "You cant really prepare yourself for something like that," Greenwood said. "After that the emotions, youve got to put them away and go after them." Seth Maness retired the last four hitters in order for his first save in his first chance of the season. NOTES: The Cardinals are 19-2 against the NL East at home the last two seasons. ... RHP Michael Wacha (4-5, 2.88 ERA) opposes Mets LHP Jonathon Niese (3-3, 2.54 ERA) on Tuesday. Wacha had a career-best 10 strikeouts and a career-worst five walks April 23 at Citi Field, when he lasted just four innings in a 3-2 loss. ... St. Louis Rams draft picks in the final week of OTAs attended the game. ... The attendance of 42,808 was the Cardinals 18th sellout of the season. 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