Wimbledon, England (SportsNetwork.com) - World No. 1 Rafael Nadal and Swiss stars Roger Federer and Stan Wawrinka were a trio of opening-round winners Tuesday at Wimbledon. The second-seeded Nadal had to come from behind to beat capable Slovak Martin Klizan 4-6, 6-3, 6-3, 6-3 on the famed Centre Court and corral career match win No. 700. "That means that I had a very long and successful career, so Im happy for that," Nadal said. "But the most important thing for me today more than 700 victories is a victory here in the first round." The 14-time Grand Slam champion Nadal was a first-round loser here a year ago. The reigning French Open champ is now 37-7 lifetime at Wimbledon, where hes a two-time titlist and three-time runner-up. Nadals second-round opponent will be big-serving Czech Lukas Rosol, who shocked the mighty Spaniard in the second round here two years ago. "Hes a very dangerous player, very strong, very powerful shots from the baseline," Nadal said of Rosol. "I have to play very well if I want to have chances to win." The fourth-seeded former world No. 1 Federer improved to 68-8 lifetime at The Championships with a comprehensive 6-1, 6-1, 6-3 handling of Italian Paolo Lorenzi in 1 hour, 33 minutes on the No. 1 Court at the All England Club. Federer broke Lorenzi six times, while the Italian went 0-for-5 on his break chances. Federer and Lorenzi are both 32 years old, but thats where the similarities end. For Lorenzi, the loss extended his winless career Grand Slam record to 0-13. Only one player, Juan-Antonio Marin of Costa Rica, has a worse record, with zero wins and 17 losses. The 17-time Grand Slam king Federer, who titled on grass in Halle two weeks ago, is a seven-time Wimbledon champ and former runner-up. Federers second-round opponent will be Luxembourg left-hander Gilles Muller. The fifth-seeded Wawrinka, meanwhile, avoided another first-round exit at tennis most prestigious event, as the Swiss strongman defeated Portugals Joao Sousa 6-3, 6-4, 6-3 to reach the second round for the first time since 2011. Wawrinka fired 18 aces and dropped only seven points on his first serve in the 1-hour, 35-minute match. The reigning Australian Open champ was stunned by Guillermo Garcia-Lopez in the first round of the French Open last month and suffered opening-round Wimbledon setbacks the previous two years. Up next for Wawrinka will be Taiwans Yen-Hsun Lu. Tenth-seeded Japanese Kei Nishikori, 13th-seeded Frenchman Richard Gasquet, 14th-seeded French star Jo-Wilfried Tsonga, and 15th-seeded Pole Jerzy Janowicz also advanced. Nishikori committed only nine unforced errors in a 6-4, 7-6 (7-5), 7-5 victory over Frances Kenny De Schepper, while Gasquet outlasted game Brit James Duckworth 6-7 (3-7), 6-3, 3-6, 6-0, 6-1 and the two-time Wimbledon semifinalist Tsonga quickly closed out a five-set victory over Austrian Jurgen Melzer. Tsonga was up 5-4 in the deciding set when the match was suspended on Monday because of rain. He completed a 6-1, 3-6, 3-6, 6-2, 6-4 win with a love service game on Day 2. A surprise semifinalist at the AEC last year, the 6-foot-8 Janowicz outlasted Indias Somdev Devvarman, 4-6, 6-3, 6-3, 3-6, 6-3, on Tuesday. Grass-court-loving Spaniard Feliciano Lopez, seeded 19th, got past Japans Yuichi Sugita 7-6 (8-6), 7-6 (8-6), 7-6 (9-7). The veteran left-hander Lopez, whos a three-time Wimbledon quarterfinalist, is now 10-1 on grass this year, including a title in Eastbourne last week and a runner-up finish at The Queens Club in London the week before. Also, 22nd-seeded German Philipp Kohlschreiber doused Dutchman Igor Sijsling 6-4, 6-4, 6-2; 24th-seeded Frenchman Gael Monfils got past Tunisian Malek Jaziri 7-6 (7-5), 7-5, 6-4; Serb Dusan Lajovic took out a 28th-seeded Garcia- Lopez 7-6 (7-5), 6-2, 3-6, 3-6, 6-3; 30th-seeded Spaniard Marcel Granollers snuck past Frenchman Nicolas Mahut 6-4, 7-6 (8-6), 6-7 (7-9), 6-4; and Uzbekistans Denis Istomin dismissed 32nd-seeded Russian Dmitry Tursunov 7-5, 6-4, 3-6, 6-2. Former Wimbledon champ Lleyton Hewitt reached the round of 64 by holding off Pole Michal Przysiezny 6-2, 6-7 (14-16), 6-1, 6-4. The 33-year-old former world No. 1 Hewitt is a two-time Grand Slam winner, including a Wimbledon title in 2002. He should have his hands full with another Pole, the towering Janowicz, on Thursday. Several other men advanced, including Rosol, Muller, Lu, Polish 2013 Wimbledon quarterfinalist Lukasz Kubot, and Americans Denis Kudla, Jack Sock and Sam Querrey. 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